Open AccessFunctional antibodies to leukocyte adhesion molecules in antithymocyte globulins1
Author(s) -
M Michallet,
Xavier Préville,
Monique Flacher,
Sylvie Fournel,
Laurent Genestier,
JeanPierre Revillard
Publication year - 2003
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000053198.99206.e6
Subject(s) - lymphocyte function associated antigen 1 , integrin , cell adhesion molecule , cd18 , chemotaxis , microbiology and biotechnology , cell adhesion , polyclonal antibodies , monocyte , cd11a , immunology , lymphocyte , monoclonal antibody , biology , antibody , chemistry , receptor , intercellular adhesion molecule 1 , cell , biochemistry
Polyclonal antithymocyte globulins (ATG) induce T-cell depletion and functional impairment of nondeleted lymphocytes. Interference of ATG with the main leukocyte surface molecules involved in cellular adhesion and leukocyte-endothelium interaction was investigated in the present study.