Open AccessIslet transplantation in the discordant tilapia-to-mouse model: a novel application of alginate microencapsulation in the study of xenograft rejection
Author(s) -
Brendan C. Dickson,
Hua Yang,
H.F.J. Savelkoul,
Geoff Rowden,
Nico van Rooijen,
James R. Wright
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000048226.28357.0d
Subject(s) - islet , transplantation , monoclonal antibody , antibody , peritoneal cavity , immunology , medicine , cd8 , t cell , streptozotocin , cancer research , immune system , biology , diabetes mellitus , endocrinology , anatomy
Tilapia islet xenograft rejection is characterized by infiltration with macrophages (Mphis), eosinophils (Ephis), and T lymphocytes. The presence of these cells indicates they contribute to rejection; therefore, an attempt was made to assess their role through host immunomodulation.