Open AccessLong-term liver allograft survival induced by combined treatment with rAAV-hCTLA4Ig gene transfer and low-dose FK5061
Author(s) -
Zhenfan Yang,
Xiaobing Wu,
Ting Y. Tsui,
Yong Hou,
John M. Luk,
Sheung–Tat Fan
Publication year - 2003
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/01.tp.0000046938.50680.c4
Subject(s) - medicine , genetic enhancement , cd8 , liver transplantation , transplantation , immunology , adeno associated virus , cytotoxic t cell , recombinant dna , antigen , biology , gene , in vitro , vector (molecular biology) , biochemistry
Recombinant adeno-associated virus vector (rAAV) is a promising vehicle for gene delivery, but few reports have documented its application in solid organ transplantation. In a rat orthotopic liver transplantation model, we investigated the efficacy of rAAV-mediated human cytotoxic T-lymphocyte-associated antigen 4 and immunoglobulin G (hCTLA4Ig) gene transfer to induce long-term allograft survival.