Open AccessThe PI3K/Akt Pathway Mediates the Nongenomic Cardioprotective Effects of Estrogen Following Trauma-hemorrhage
Author(s) -
Hao Yu,
Ya Ching Hsieh,
Takao Suzuki,
Mashkoor A. Choudhry,
Martin G. Schwacha,
Kirby I. Bland,
Irshad H. Chaudry
Publication year - 2007
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000254417.15591.88
Subject(s) - wortmannin , medicine , pi3k/akt/mtor pathway , protein kinase b , cardiac function curve , endocrinology , estrogen , resuscitation , stroke volume , estrogen receptor , apoptosis , pharmacology , anesthesia , heart rate , blood pressure , heart failure , biology , biochemistry , cancer , breast cancer
To determine whether the nongenomic actions of E2 have any beneficial effect on cardiac function following trauma-hemorrhage and whether those effects are mediated via the PI3K/Akt pathway.