Open AccessGene Expression Profiles Differentiate Between Sterile SIRS and Early Sepsis
Author(s) -
Steven B. Johnson,
Matthew Lissauer,
Grant V. Bochicchio,
Richard B. Moore,
Alan S. Cross,
Thomas M. Scalea
Publication year - 2007
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000251619.10648.32
Subject(s) - sepsis , medicine , systemic inflammatory response syndrome , gene expression , gene , phenotype , immunology , gene expression profiling , microarray , etiology , bioinformatics , biology , genetics
The systemic inflammatory response syndrome (SIRS) occurs frequently in critically ill patients and presents similar clinical appearances despite diverse infectious and noninfectious etiologies. Despite similar phenotypic expression, these diverse SIRS etiologies may induce divergent genotypic expressions. We hypothesized that gene expression differences are present between sepsis and uninfected SIRS prior to the clinical appearance of sepsis.