Open AccessIncreased CD4+ CD25+ T Regulatory Cell Activity in Trauma Patients Depresses Protective Th1 Immunity
Author(s) -
Malcolm MacConmara,
Adrian A. Maung,
Satoshi Fujimi,
Ann Marie McKenna,
Adam Delisle,
Peter H. Lapchak,
Selwyn Rogers,
James A. Lederer,
John A. Mannick
Publication year - 2006
Publication title -
transactions of the meeting of the american surgical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
ISSN - 0066-0833
DOI - 10.1097/01.sla.0000239031.06906.1f
Subject(s) - il 2 receptor , immunology , cytokine , medicine , cd28 , t cell , immunity , regulatory t cell , immune system , interleukin 10
We recently reported increased CD4 CD25 T regulatory (Treg) activity after burn injury in mice. This study sought to determine if Tregs mediate the reduction in TH1-type immunity after serious injury in man and if Treg function is altered by injury.