Open AccessStatins (HMG-CoA Reductase Inhibitors) Decrease Postoperative Adhesions by Increasing Peritoneal Fibrinolytic Activity
Author(s) -
Cary B. Aarons,
Philip Cohen,
Adam C. Gower,
Karen L. Reed,
Susan E. Leeman,
Arthur F. Stucchi,
James M. Becker
Publication year - 2007
Publication title -
annals of surgery
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000236627.07927.7c
Subject(s) - medicine , atorvastatin , t plasminogen activator , lovastatin , tissue plasminogen activator , fibrinolysis , plasminogen activator , pharmacology , wound healing , farnesyl pyrophosphate , plasminogen activator inhibitor 1 , surgery , cholesterol , biochemistry , enzyme , biology , biosynthesis
The aims of this study were to determine if statins reduce adhesion formation in vivo and to identify the mechanism of action in vitro.