Open AccessHigh Intra-abdominal Pressure Enhances the Penetration and Antitumor Effect of Intraperitoneal Cisplatin on Experimental Peritoneal Carcinomatosis
Author(s) -
Philippe Esquis,
David Consolo,
Guy Magnin,
Philippe Pointaire,
Philippe Moretto,
M.D. Ynsa,
Jean-Luc Beltramo,
C. Drogoul,
Michel Simonet,
Laurent Beaugerie,
Patrick Rat,
Bruno Chauffert
Publication year - 2006
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000218089.61635.5f
Subject(s) - medicine , peritoneal carcinomatosis , cisplatin , peritoneum , intraperitoneal chemotherapy , penetration (warfare) , oncology , pathology , chemotherapy , cancer , ovarian cancer , colorectal cancer , operations research , engineering
To investigate the role of increased intra-abdominal pressure (IAP) on the intratumoral accumulation and the antitumor effect of intraperitoneal cisplatin in rats with advanced peritoneal carcinomatosis. To evaluate the tolerance of IAP in pigs, as it is a large animal with a body size equivalent to humans.