Open AccessA Randomized Controlled Trial of 0.5% Ferric Hyaluronate Gel (Intergel) in the Prevention of Adhesions Following Abdominal Surgery
Author(s) -
Choong Leong Tang,
David Jayne,
Francis SeowChoen,
Yen-Yee Ng,
KongWeng Eu,
Noriza Mustapha
Publication year - 2006
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000207837.71831.a2
Subject(s) - medicine , surgery , randomized controlled trial , anastomosis , abdominal surgery , sequela , dehiscence , clinical endpoint , bowel obstruction , incidence (geometry) , adhesion , chemistry , physics , organic chemistry , optics
Intestinal adhesion following abdominal surgery is a significant sequela to abdominal surgery. Intergel is a hyaluronate-based gel that reduces the incidence of postoperative adhesions when added to the peritoneal cavity before closure in gynecologic surgery. This is a randomized controlled trial evaluating the efficacy and safety of Intergel in colorectal resections. Although the study aimed to recruit 200 patients based on power analysis, recruitment was suspended because of the high morbidity in the treatment group.