Open AccessModulation of E-Cadherin by Hepatocyte Growth Factor Induces Aggressiveness of Gastric Carcinoma
Author(s) -
SangUk Han,
Hwa Young Lee,
Jae-Ho Lee,
Wook Hwan Kim,
Hyun-Ja Nam,
Hong Kim,
Yong-Kwan Cho,
Myung-Wook Kim,
Kuhn Uk Lee
Publication year - 2005
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000186171.85804.fe
Subject(s) - hepatocyte growth factor , cadherin , medicine , pathology , cancer research , matrigel , c met , western blot , carcinoma , cell , biology , receptor , angiogenesis , gene , biochemistry , genetics
Hepatocyte growth factor (HGF) is well known as a scatter factor because it can disperse cells. E-cadherin is a protein that plays a main role in the establishment of cell-cell adhesion. This study focused on the role of HGF on the expression and distribution of E-cadherin. Furthermore, we found induction of aggressiveness of gastric carcinoma by modulation of E-cadherin by HGF.