Open AccessInfluence of Metformin on Glucose Intolerance and Muscle Catabolism Following Severe Burn Injury
Author(s) -
Dennis C. Gore,
Steven E. Wolf,
Arthur P. Sanford,
David N. Herndon,
Robert R. Wolfe
Publication year - 2005
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000152013.23032.d1
Subject(s) - metformin , medicine , endocrinology , placebo , protein catabolism , carbohydrate metabolism , catabolism , wasting , diabetes mellitus , metabolism , biochemistry , chemistry , alternative medicine , amino acid , pathology
Hyperglycemia and accelerated muscle catabolism have been shown to adversely affect immune response and survival. The purpose of this study was to determine the effect of metformin on glucose kinetics and muscle protein metabolism in severely burned patients and assess any potential benefit of metformin in this clinical setting.