Open AccessClinical Significance of Dihydropyrimidine Dehydrogenase in Adjuvant 5-Fluorouracil Liver Perfusion Chemotherapy for Pancreatic Cancer
Author(s) -
Shigeki Nakayama,
Shin Takeda,
Yoshihisa Kawase,
Soichiro Inoue,
Tetsuya Kaneko,
Akimasa Nakao
Publication year - 2004
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000143300.49878.51
Subject(s) - medicine , dihydropyrimidine dehydrogenase , fluorouracil , chemotherapy , perfusion , liver perfusion , oncology , adjuvant chemotherapy , adjuvant , cancer , gastroenterology , thymidylate synthase , breast cancer
To clarify the relationship between intratumoral dihydropyrimidine dehydrogenase (DPD) expression and response to 5-fluorouracil (5-FU) liver perfusion chemotherapy (LPC) in pancreatic cancer patients, we evaluated DPD expression immunohistochemically in resected pancreatic cancer tissues.