Open AccessA Pentadecapeptide Fragment of Islet Neogenesis-Associated Protein Increases Beta-Cell Mass and Reverses Diabetes in C57BL/6J Mice
Author(s) -
Lawrence Rosenberg,
Mark Lipsett,
JiWon Yoon,
Marc Prentki,
Rennian Wang,
Youn-Jung Lee,
Gary L. Pittenger,
David A. TaylorFishwick,
Aaron I. Vinik
Publication year - 2004
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000143270.99191.10
Subject(s) - neogenesis , islet , endocrinology , medicine , streptozotocin , beta cell , peptide , insulitis , pancreas , diabetes mellitus , saline , endocrine system , glucagon like peptide 1 , hormone , biology , type 2 diabetes , biochemistry
The objective of this study was to demonstrate that islet neogenesis-associated protein (INGAP) peptide, a pentadecapeptide containing the biologically active portion of native INGAP, increases functional beta-cell mass in normal animals and can be used therapeutically to reverse hyperglycemia in streptozotocin-induced diabetes.