Open AccessAdrenomedullin and Adrenomedullin Binding Protein-1 Attenuate Vascular Endothelial Cell Apoptosis in Sepsis
Author(s) -
Mian Zhou,
Henry S. Simms,
Haichao Wang
Publication year - 2004
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000133253.45591.5b
Subject(s) - adrenomedullin , sepsis , medicine , apoptosis , tunel assay , western blot , ligation , immunology , endocrinology , pharmacology , biology , immunohistochemistry , receptor , biochemistry , gene
To determine whether vascular endothelial cell apoptosis occurs in the late stage of sepsis and, if so, whether administration of a potent vasodilatory peptide adrenomedullin and its newly reported specific binding protein (AM/AMBP-1) prevents sepsis-induced endothelial cell apoptosis.