Open AccessEffect of Simultaneous Inhibition of TNF-?? Production and Xanthine Oxidase in Experimental Acute Pancreatitis
Author(s) -
Javier Pereda,
Luís Sabater,
Norberto Cassinello Fernández,
Luis G. Gómez-Cambronero,
Daniel Closa,
Emma Folch-Puy,
Luís Aparisi,
J. Ferrer Calvete,
Miguel Jover Cerdá,
Salvador Lledó,
José Viña,
Juan Sastre
Publication year - 2004
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000129343.47774.89
Subject(s) - pentoxifylline , medicine , xanthine oxidase , pancreatitis , acute pancreatitis , myeloperoxidase , xanthine oxidase inhibitor , pancreatic disease , tumor necrosis factor alpha , endocrinology , pharmacology , pancreas , inflammation , biochemistry , biology , enzyme
To assess the effects of inhibiting both tumor necrosis factor (TNF)-alpha production and xanthine oxidase activity on the inflammatory response, mitogen-activated protein kinase (MAPK) activation and mortality in necrotizing acute pancreatitis in rats.