Open AccessBone Marrow Failure Following Severe Injury in Humans
Author(s) -
Deputy Livingston,
Devashish J. Anjaria,
Jonathan C. Wu,
Carl J. Hauser,
Victor Chang,
Edwin A. Deitch,
Pranela Rameshwar
Publication year - 2003
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000094441.38807.09
Subject(s) - bone marrow , medicine , anemia , haematopoiesis , bone marrow failure , white blood cell , reticulocyte , pathology , erythropoiesis , immunology , stem cell , biology , genetics , biochemistry , messenger rna , gene
Hematopoietic failure has been observed in experimental animals following shock and injury. In humans, bone marrow dysfunction has been observed in the red cell component and characterized by a persistent anemia, low reticulocyte counts, and the need for repeated transfusions despite adequate iron stores. While a quantitative defect in white blood cell count has not been noted, an alteration in white blood cell function manifesting as an increased susceptibility to infection is well established. Since the etiology of this anemia remains unknown and the bone marrow has been rarely studied following injury, we measured various parameters of hematopoiesis directly using bone marrow from trauma patients and tested the hypothesis that trauma results in profound bone marrow dysfunction, which could explain both the persistent anemia and the alteration in white blood cell function.