Open AccessHeart Xenograft Survival With Chimeric Pig Donors and Modest Immune Suppression
Author(s) -
William E. Beschorner,
Debra L. Sudan,
Stanley J. Radio,
Tianyu Yang,
Kenneth L. Franco,
Arthur C. Hill,
C. Carson Shearon,
Scott C. Thompson,
Robert S. Dixon,
Noel D. Johnson,
Charles Kuszynski,
Ronald J. Rubocki,
Kelly F. Lechtenberg,
Aurelio Matamoros,
Timothy C. Goertzen,
Ira J. Fox,
Alan Norman Langnas
Publication year - 2003
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/01.sla.0000048456.81319.da
Subject(s) - medicine , immune system , splenocyte , transplantation , immunology , immune tolerance , miniature swine , heart transplantation , immunosuppression
To assess the use of donor pigs with cellular chimerism for prevention of acute rejection with modest immune suppression. The clinical use of pig organ xenografts is currently precluded by severe acute rejection, which resists standard immune suppression.