Open AccessTHE INHIBITION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN OVINE SEPSIS MODEL
Author(s) -
Perenlei Enkhbaatar,
Kazunori Murakami,
Lillian D. Traber,
Robert A. Cox,
John F. Parkinson,
Martin Westphal,
Aimalohi Esechie,
Naoki Morita,
Marc O. Maybauer,
Dirk M. Maybauer,
Ann S. Burke,
Frank C. Schmalstieg,
Hal K. Hawkins,
David N. Herndon,
Daniel L. Traber
Publication year - 2006
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/01.shk.0000209525.50990.28
Subject(s) - smoke inhalation , sepsis , lung , smoke inhalation injury , medicine , anesthesia , pathogenesis , nitric oxide synthase , pneumonia , inhalation , nitric oxide , respiratory system , pharmacology , immunology
Small volume resuscitation fluids continue to be of interest to the military and limited volume resuscitation is becoming more common in the treatment of hemorrhage in the civilian community. With renewed interest to undertake a large US-Canada multi-center clinical trial of hypertonic saline alone or combined with dextran (HSD) possibly in 2006, concerns related to the safe use of this product continue to surface. This review addresses the use of these products in uncontrolled hemorrhage models, in dehydration and addresses perceived risks associated with hypernatremia, dextran-associated anaphylactoid reactions and effects on coagulation and renal function.