Open AccessHARMFUL AND PROTECTIVE ROLES OF NEUTROPHILS IN SEPSIS
Author(s) -
Laszlo M. Hoesel,
Thomas Neff,
Simona B Neff,
John G. Younger,
Eric W. Olle,
Hongwei Gao,
Matthew J. Pianko,
Kurt D. Bernacki,
J. Vidya Sarma,
Peter A. Ward
Publication year - 2005
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/01.shk.0000170353.80318.d5
Subject(s) - sepsis , bacteremia , medicine , immunology , innate immune system , organ dysfunction , neutrophile , ligation , immune system , inflammation , biology , antibiotics , microbiology and biotechnology
The current studies demonstrate protective and harmful effects of neutrophils (PMN) during experimental sepsis after cecal ligation and puncture (CLP). It is known that CLP induces signaling defects in blood PMN. When PMN were depleted 12 h after CLP, there were dramatic reductions in levels of bacteremia, evidence for reduced liver and renal dysfunction, sharp reductions in serum levels of cytokines (IL-1beta, IL-6, IL-10, TNF-alpha, and IL-2), and improved survival. In contrast, PMN depletion before CLP resulted in substantial increases in bacteremia and no evidence for attenuation of liver and renal failure dysfunction. These data suggest that at the onset of sepsis, PMN are important in regulating the levels of bacteremia, whereas after the onset of sepsis, as they lose innate immune functions, their presence is associated with higher levels of bacteremia and intensified organ dysfunction.