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Effects of Halofuginone on Fibrosis Formation Secondary to Experimentally Induced Subglottic Trauma
Author(s) -
Ertuğrul E. Eylem,
Cincik Hakan,
Dogru Salim,
Cekin Engin,
Berber Ufuk,
Gungor Atila,
Poyrazoğlu I. Ethem
Publication year - 2007
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/01.mlg.0000250593.19282.47
Subject(s) - medicine , fibrosis , necrosis , pathology
Objective: The aim of the study was to assess the antifibrotic effect of systemically applied halofuginone after subglottic injury. Materials and Methods: After standardized trauma to subglottic area, rats were divided into two groups: a study group that received treatment and a control group that did not. The rats were treated with 0.1 mg/kg/day intraperitoneal halofuginone injection for 30 days. The larynx specimens were examined histopathologically under light microscope for epithelization, inflammation, necrosis, and fibrosis. Results: The fibrosis indexes of the treated group were significantly less than those of the control group ( P < .01). Conclusions: Systemically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.