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A Paranasal Tumor Associated With Tumor‐Induced Osteomalacia
Author(s) -
Inokuchi Go,
Tanimoto Hitoshi,
Ishida Haruhiko,
Sugimoto Toshitsugu,
Yamauchi Mika,
Miyauchi Akimitsu,
Nibu Kenichi
Publication year - 2006
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/01.mlg.0000231295.67060.89
Subject(s) - medicine , fibroblast growth factor 23 , osteomalacia , craniofacial , sinus (botany) , paranasal sinuses , pathology , fibroblast growth factor , gastroenterology , surgery , osteoporosis , parathyroid hormone , botany , psychiatry , genus , biology , calcium , receptor
Background: Tumor‐induced osteomalacia (TIO) is an extremely rare paraneoplastic syndrome associated with mesenchymal tumors in the craniofacial region. Methods: We treated a 24‐year‐old Japanese woman with paranasal sinus tumor and a low serum phosphate level who presented with nasal obstruction and systemic bone fractures. Serum fibroblast growth factor 23 (FGF‐23) was measured before and after surgery. Results: After surgery, her symptoms were resolved and the serum phosphate and FGF‐23 levels became normalized. Conclusion: FGF‐23 is thought to be a useful diagnostic marker in patients with craniofacial tumors associated with multiple systemic fractures.