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The 30‐bp Deletion of Epstein‐Barr Virus Latent Membrane Protein‐1 Gene Has No Effect in Nasopharyngeal Carcinoma
Author(s) -
Chang KaiPing,
Hao ShengPo,
Lin ShinnYn,
Ueng ShirHwa,
Pai PingChing,
Tseng ChenKan,
Hsueh Chuen,
Hsieh MengShu,
Yu JauSong,
Tsang NganMing
Publication year - 2006
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/01.mlg.0000201993.53410.40
Subject(s) - nasopharyngeal carcinoma , retrospective cohort study , medicine , cohort , stage (stratigraphy) , statistical significance , oncology , metastasis , pathogenesis , radiation therapy , gastroenterology , multivariate analysis , biology , cancer , paleontology
Objective: The specific 30‐bp deletion of the Epstein‐Barr virus (EBV)‐derived latent membrane protein‐1 gene has been suggested to be associated with the pathogenesis of nasopharyngeal carcinoma (NPC) and a more aggressive phenotype of some EBV‐associated malignancies. Methods: The authors conducted a retrospective cohort study. Between 1995 and 2001, 542 patients who had received complete courses of radiotherapy followed by at least 3 years of follow up were enrolled. Patients were divided into two groups according to the presence or absence of the 30‐bp deletion in their tumor samples. Results: A total of 446 (82.3%) patients were found to feature the 30‐bp deletion, whereas 88 (16.2%) did not. Interestingly, dual infection was found in eight (1.5%) patients. No statistical significance was found in age, gender, NPC‐presenting stage, radiosensitivity, and pathologic classification between the two groups. The actuarial 5‐year overall survival rate and the distant metastasis‐free rate for the 30‐bp deletion and nondeletion group were not statistically different (61.3% vs. 65.4% and 68.1% vs. 73.1%; P = .132 and .135, respectively). In multivariate analysis, older age, nasopharyngeal recurrence, advanced tumor stage, and the development of distant metastasis were shown to be poorer prognosticators for overall survival, whereas the presence of 30‐bp deletion was not. For distant metastasis, only advanced tumor stage was shown to be a poor prognosticator, whereas other variables, including the presence of 30‐bp deletion, had no statistical significance. Conclusions: In this retrospective cohort, we have demonstrated that this specific 30‐bp sequence deletion might be only the predominant variant rather than an NPC phenotype‐associated polymorphism. Additionally, dual infection is a rare but possible phenomenon in the endemic NPC tumors.