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Total Pharyngolaryngectomy for Squamous Cell Carcinoma of the Hypopharynx: A Review
Author(s) -
Bova Ronaldo,
Goh Raymond,
Poulson Michael,
Coman William B.
Publication year - 2005
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1097/01.mlg.0000158348.38763.5d
Subject(s) - medicine , hypopharyngeal cancer , stage (stratigraphy) , lymphovascular invasion , perineural invasion , univariate analysis , otorhinolaryngology , t stage , multivariate analysis , oncology , retrospective cohort study , head and neck cancer , cancer , surgery , metastasis , paleontology , biology
Objectives: To evaluate our experience with total pharyngolaryngectomy in the treatment of hypopharyngeal squamous cell carcinoma. Study Design: Retrospective analysis of consecutively treated patients in an academic otolaryngology, head and neck department. Methods: One hundred eighty patients who had total pharyngolaryngectomy performed for hypopharyngeal carcinoma were included in this study. Patients with a history of previous head and neck cancer were excluded. Clinicopathologic parameters were recorded and survival calculated using the Kaplan‐Meier method. Results: One hundred sixty‐two (90%) of the patients were male, and the patients had a mean age of 62 years. The majority (91%) of patients had advanced overall clinical stage disease (stage 3,4). Thirty‐one (17.8%) and 43 (24%) patients developed locoregional and metastatic disease recurrence, respectively. The 2‐ and 5‐year disease‐specific survival rates were 72% and 52%, respectively. Advanced nodal stage, perineural invasion, lymphovascular invasion, and positive margins were predictors of poor survival on univariate analysis, and lymphovascular invasion was an independent prognostic factor on multivariate analysis. Conclusion: Surgery and postoperative radiotherapy remains the treatment against which other modalities should be compared for advanced stage hypopharyngeal squamous cell carcinoma.