Open AccessProgress in the Development of the DexAide Right Ventricular Assist Device
Author(s) -
Kiyotaka Fukamachi,
Yoshio Ootaki,
David J. Horvath,
Alex Massiello,
Keiji Kamohara,
Mitoshi Akiyama,
Faruk Cíngöz,
Chiyo Ootaki,
Michael W. Kopcak,
Raymond Dessoffy,
Jenny Liu,
Ji Feng Chen,
Qun Zhou,
Stephen Benefit,
Leonard A.R. Golding,
Sue Alfini,
David Rowe
Publication year - 2006
Publication title -
asaio journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 66
eISSN - 1538-943X
pISSN - 1058-2916
DOI - 10.1097/01.mat.0000240700.03478.d0
Subject(s) - cannula , in vivo , hemodynamics , medicine , biomedical engineering , centrifugal pump , electronics , cardiology , surgery , mechanical engineering , electrical engineering , engineering , impeller , biology , microbiology and biotechnology
The DexAide right ventricular assist device (RVAD) is an implantable centrifugal pump modified from the CorAide left ventricular assist device. As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm Hg pressure rise was achieved at 2,000 rpm, with a power consumption of 1.9 watts. In vivo studies in 14 calves have demonstrated acceptable hemodynamic characteristics. The calf inflow cannula design is still evolving to minimize depositions on the cannula observed in most experiments. Fitting studies were performed in 5 cadavers and 2 patients to reconfigure the cannulae for use in humans. The design and development of external electronics have been completed for the stand-alone RVAD system, and verification tests are under way in preparation for preclinical tests. Work on the external electronics design for the biventricular assist system is ongoing. In conclusion, the initial in vitro and in vivo studies have demonstrated acceptable hemodynamic characteristics of the DexAide RVAD. The design and development of the external electronic components for the stand-alone RVAD system have been completed. The calf inflow cannula is being redesigned, and chronic in vivo tests are under way.