Open AccessDevelopment of a Small Implantable Right Ventricular Assist Device
Author(s) -
Kiyotaka Fukamachi,
David J. Horvath,
Alex Massiello,
Yoshio Ootaki,
Keiji Kamohara,
Mitoshi Akiyama,
Firas Zahr,
Michael W. Kopcak,
Raymond Dessoffy,
Ji Feng Chen,
Stephen Benefit,
Leonard A.R. Golding
Publication year - 2005
Publication title -
asaio journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.961
H-Index - 66
eISSN - 1538-943X
pISSN - 1058-2916
DOI - 10.1097/01.mat.0000181031.66900.b6
Subject(s) - afterload , medicine , ventricular assist device , cardiology , biomedical engineering , heart failure , hemodynamics
The purpose of this program is to design, develop, and clinically evaluate a new, implantable right ventricular assist device (RVAD) that can be used as a component of an implantable biventricular assist device for patients with severe biventricular heart failure. The initial phase of this program resulted in a prototype RVAD, named DexAide, a modified version of the CorAide left ventricular assist device. In vitro testing was performed in a stand-alone circuit and in a true RVAD mode to evaluate pump performance. Pump flow and power were measured under various afterload and pump speed conditions. The pump performance requirements of 2 to 6 l/min and a pressure rise of 20 to 60 mm Hg were successfully met with pump speeds between 1,800 and 3,200 rpm. The nominal design point of 4 l/min and 40 mm Hg pressure rise was achieved at 2,450 +/- 70 rpm with a power consumption of 3.0 +/- 0.2 W. The initial in vitro testing met the design criteria for the new DexAide RVAD. Initial in vivo testing is under way, which will be followed by preclinical readiness testing and a pilot clinical trial in this 5-year program.