Open AccessA review of inherited cancer susceptibility syndromes
Author(s) -
Gina Brown,
Madeline Simon,
Chris Wentling,
Danielle M Spencer,
Ashley Parker,
Corey A Rogers
Publication year - 2020
Publication title -
journal of the american academy of physician assistants
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.24
H-Index - 17
ISSN - 0893-7400
DOI - 10.1097/01.jaa.0000721648.46099.2c
Subject(s) - retinoblastoma , medicine , family history , ovarian cancer , cancer , cancer syndrome , li–fraumeni syndrome , familial adenomatous polyposis , genetic counseling , genetic testing , breast cancer , colorectal cancer , inheritance (genetic algorithm) , genetics , germline mutation , mutation , biology , gene
Inherited cancer syndromes are caused by genetic mutations that place patients at an increased risk for developing cancer. Although most cancers are not caused by genetic inheritance, clinicians must understand these syndromes and be able to recognize their common characteristics. A thorough family history and identification of common patterns as well as specific clinical signs and symptoms can help with early recognition. This article describes symptoms of the more common cancer syndromes, including hereditary breast and ovarian cancer, Li-Fraumeni, Lynch, familial adenomatous polyposis, retinoblastoma, multiple endocrine neoplasia, and von Hippel-Lindau. Important patient education regarding genetic testing also is covered.