Open Access“Hit-and-Run” Effects of Paramyxoviruses as a Basis for Chronic Respiratory Disease
Author(s) -
Michael J. Holtzman,
Laurie P. Shornick,
Mitchell H. Grayson,
Edy Y. Kim,
Jeffrey W. Tyner,
Anand C. Patel,
Eugene Agapov,
Yong Zhang
Publication year - 2004
Publication title -
the pediatric infectious disease journal/the pediatric infectious disease journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 140
eISSN - 1532-0987
pISSN - 0891-3668
DOI - 10.1097/01.inf.0000144674.24802.c1
Subject(s) - immunology , immune system , pathogenesis , acquired immune system , asthma , disease , inflammation , innate immune system , immunity , medicine , biology , pathology
The traditional scheme for asthma pathogenesis depends on increased T helper type 2 (Th2) over T helper type 1 (Th1) responses to allergic and nonallergic stimuli and consequent airway inflammation, hyperreactivity and hypersecretion. Here we question whether the innate immune system, including airway epithelial cells, and the adaptive one may manifest an aberrant antiviral response as an additional basis for chronic inflammatory diseases, including asthma.