Open AccessPB2431 CAROTID INTIMA‐MEDIA THICKNESS PROGRESSION AND BLOOD COAGULATION FACTOR XIII LEVELS IN TYPE 2 DIABETES: 8 YEARS OF FOLLOW‐UP
Author(s) -
Sadeghi F.,
Cogoi B.,
Káplár M.,
Csiki Z.,
Kovács S.,
Katona É.,
Muszbek L.,
Shemirani A. H.
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/01.hs9.0000568184.47926.45
Subject(s) - medicine , intima media thickness , prospective cohort study , factor xiii , diabetes mellitus , fibrinolysis , antigen , gastroenterology , fibrinogen , immunology , carotid arteries , endocrinology
Background: Blood coagulation factor XIII (FXIII) main function is to strengthen and consequently protect fibrin polymers from fibrinolysis. Associations of transglutaminases in general, FXIII in particular and atherogenesis are described in the literature. Carotid intima‐media thickness (CIMT) has been shown to be a proxy end point for future vascular events. CIMT is related to premature atherosclerosis in healthy young adults. Aims: In this prospective study, the objective was to assess the relation between FXIII antigen, activity, CIMT at follow‐up as well as for CIMT progression (ΔCIMT). Methods: This prospective study comprised of 118 patients (56 females, 62 males, mean age of 62 ± SD10 years). All participants in the study cohort offered clinical, biochemical and ultrasonography investigations at baseline and at follow‐up. Results: During the period of investigation, mean CIMT, FXIII cross‐linking activity and antigen levels, both non‐adjusted and adjusted for the respective independently associated parameters, were significantly higher (p < 0.001). We divided the patients in tertiles of FXIII activity and antigen. At baseline, number of patients decreased as FXIII cross‐linking activity increased. It was reversed at follow‐up and significantly higher number of patients were present at upper tertile compare with lower tertile (p = 0.023). We observed similar results in case of FXIII antigen (p < 0.001). Summary/Conclusion: In conclusion, FXIII antigen and activity are elevated in individuals with type 2 diabetes. Increased CIMT and its progression was observed in this group of patients.