PB2318 DOUBLE HETEROZYGOSITY S/C AT HEMATOLOGY DEPARTMENT ANNABA HOSPITAL ‐ALGERIA

Background: Major sickle cell disorders account for 95% of the hemoglobinopathies supported at our service; double S/C heterozygosity is infrequent and represents only 6,4%. Aims: The objective of our work is to determine the prevalence and characteristics of acute and chronic complications that occurred in our patients during their follow‐up. Methods: This is a retrospective, descriptive study of 99 patients with double S / C heterozygosity and followed regularly since recruitment until December 2017. The patients benefit from a regular follow‐up, every 04 months with an annual report aimed at detecting the chronic complications. Results: The average age of patients at the time of diagnosis is 21 years, with extremes of [02‐49 years]. The current average age of the cohort is 33 years, with extremes of [13‐66 years] The majority of our patients come from Algerian‐Tunisian border area (79%). During this monitoring, several variously associated complications were collected: The acute complications are dominated by vaso‐occlusive crises in various locations, with exceptionnellent‐required hospitalization; During follow‐up, 32.09% of our patients developed various chronic complications: Summary/Conclusion: Despite of an acute symptomatology low noise from the S/C, chronic complications are frequent, imposing the implementation of a multidisciplinary management strategy at our level.