Open AccessPB2159 CHOLESTEROL LEVELS PROVIDE PROGNOSTIC INFORMATION IN PATIENTS WITH MULTIPLE MYELOMA
Author(s) -
Peipei X.
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/01.hs9.0000567120.09086.a3
Subject(s) - medicine , cholesterol , multiple myeloma , multivariate analysis , gastroenterology , retrospective cohort study , total cholesterol , cancer , ldl cholesterol , high density lipoprotein , oncology
Background: Hypocholesterolaemia has been reported to be associated with cancer risk and progression. Aims: he aim of this retrospective study was to investigate the prognostic value of cholesterol levels in patients with multiple myeloma (MM). Methods A total of 153 patients newly diagnosed with MM were retrospectively enrolled. The relationship between cholesterol levels and clinical characteristics was evaluated. The prognostic value of cholesterol levels was explored. Results: The levels of low‐density lipoprotein cholesterol (LDL‐c), high‐density lipoprotein cholesterol (HDL‐c) and triglycerides (TC) were significantly lower in MM patients (P < 0.001). What is more, multivariate analyses showed that low TC and LDL‐c levels were independent predictors of a better OS (overall survival; HR = 6.893 and 0.204; CI = 1.135‐41.868 and 0.045‐0.930, P = 0.036 and 0.040) and PFS (progression‐free survival; HR = 7.416 and 0.216; CI = 1.365‐40.290 and 0.047‐0.999, P = 0.020 and 0.049). Summary/Conclusion: Serum cholesterol levels in MM patients were low, and TC and LDL‐c levels could be used as prognostic markers for MM patients.