Open AccessPB2136 DO FUNCTIONAL VARIANTS OF MIF AND MBL GENES INFLUENCE OUTCOME IN PATIENTS UNDERWENT AUTOLOGOUS STEM CELL TRANSPLANTATION FOR MULTIPLE MYELOMA?
Author(s) -
Pehlivan M.,
Nursal A. F.,
Gündeş I.,
Oyacı Y.,
Kıvanç D.,
Pehlivan S.
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/01.hs9.0000567028.92945.e5
Subject(s) - macrophage migration inhibitory factor , autologous stem cell transplantation , genotype , medicine , multiple myeloma , gastroenterology , transplantation , oncology , immunology , proportional hazards model , biology , cytokine , gene , genetics
Background: Multiple myeloma (MM) is a plasma cell malignancy, with wide survival range and multiple risk factors and staging systems linked to survival. Macrophage migration inhibitory factor (MIF) is a potent proinflammatory cytokine. Mannose‐binding lectin (MBL) enhances opsonization and activates complement. Aims: This analysis was performed to evaluate the relationships of MIF ‐173G/C and MBL codon 54 variants with clinical feaures and susceptibility in patients underwent Autologous stem cell transplantation (ASCT) for MM. Methods A total of 155 patients (Female/Male:74/81) who underwent ASCT and 200 healthy subjects (Female/Male:99/101) were included. The median follow‐up period was 36 months. Genotyping of these variants was determined by PCR‐RFLP. Genotype and allele frequencies were compared between the study groups using χ 2 ‐test. Kaplan‐Meier curves for Progression‐free survival (PFS) and Overall survival (OS) were compared using a log‐rank test. Results: The median age at diagnosis is 55 years for patients. In all, median OS was 79 months in patients. OS showed that 16.1% patients died. PFS was associated with gender ( p = 0.049, 95% Cl:0.258‐0.998). Individuals with BB genotype showed a significant association with 10.607‐fold increased risk of MM ( p = 0.001 ). The genetic analysis association with survival was performed under a recessive genetic model (CC vs. GG/CG). MIF GC/GG genotype was significantly associated with longer OS (median 5 years) compared to CC genotypes (Log Rank p = 0.016 ). Summary/Conclusion: Our study indicated that the MBL codon 54 functional variant might contribute to MM susceptibility in Turkish population. Also our results imply that the OS in MM patients is associated with the ‐173G/C variant of MIF gene.