Open AccessPB2038 EVOLUATION OF CLINICAL MANIFESTATION IN FEBRILE NEUTROPENIC PATIENTS
Author(s) -
Bekoz H.S.,
Kaya Z.,
Mert A.
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/01.hs9.0000566640.25148.6d
Subject(s) - meropenem , medicine , cefepime , piperacillin , neutropenia , blood culture , febrile neutropenia , tazobactam , antibiotics , teicoplanin , intensive care medicine , antibiotic resistance , imipenem , chemotherapy , microbiology and biotechnology , vancomycin , pseudomonas aeruginosa , staphylococcus aureus , biology , bacteria , genetics
Background: Neutropenia is one of the most life‐threatening and significant complication of intensive chemotherapy treatments. Febrile neutropenia is the major cause of mortality and morbidity in these patients (1). Aims: The aim of this study, was to evaluate the epidemiology and the surveillance factors in febrile neutropenic patients retrospectively. Methods: This study was undertaken in the our university from December 2014 to December 2017. Blood culture was studied by Bact‐Alert automated system.Antibiotic susceptibility tests were Kirby Baver Discus Fusion Method. Results: A total of 195 patients, 400 febrile neutropenic attacks were assessed. During FEN episodes, 178 of the patients (45%) had piperacillin‐tazobactam, 145(45%) had meropenem, 195(49%) had teicoplanin and 17(4%) had cefepime.In our study, microbiologically documented infection was 31%, clinically documanted infection was 33%, and responding to empirical antibiotic infection was 43%.In our study, 83 blood culture positivity were studied for resistance, 33 (40%) of them had ESBL and 19 (23%) had carbapenemase‐producing microorganisms.Summary/Conclusion: For the management and determining empirical antibiotic policies, it is important to identify their pathogenic microorganisms, to determine their antimicrobial susceptibility for improving survival rates in FEN process. In our study, infections foci, culture positivity rates, isolated microorganisms consistent with the rates reported in the literature.