Open AccessPB2036 EFFECTS OF DIFFERENT IRON FORMULATION SUPPORT ON SELECTION OF SOME PATHOGENS IN HUMAN GUT FLORA: MONOCENTRIC STUDY
Author(s) -
Giordano G.,
Lucchesi A.,
magri M.,
niro G.,
gasperi M.
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/01.hs9.0000566632.79406.6d
Subject(s) - pathogen , microbiology and biotechnology , yersinia , shigella , enteropathogenic escherichia coli , flora (microbiology) , salmonella , micronutrient , shigella flexneri , medicine , biology , bacteria , escherichia coli , pathology , biochemistry , genetics , gene
Background: Food and micronutrients support modify the composition of our intestinal flora. Aims: Aim of this study is to see how different iron formulations used in human iron support are able to expand gut pathogen flora. Methods: 36 female patients (6 per group) with sideropenic anemia due to hypermenorrhea received 60 mg/day of different iron formulations: sulphate, Sucrosomial®, heminic bisglycinated, bisglycinated chelated, micronized encapsulated. Median age of patients was 30y (R20‐38). A stool culture test was performed in each patient at start of treatment and one month after. If at time 0 a culture was positive for a pathogen, patient was excluded from the study. Cultural stool test were performed for E. coli enteropathogen, enterohemorragic, salmonella, shigella, clostridium, yersinia entherocolica. Results: Before treatment: 1 patient receiving iron sulphate had a yersinia positivity and 1 receiving heminic bisglycinated iron showed an E. coli. After treatment: 2 patients receiving heminic bisglycynated iron showed positivity for E. coli enteropathogenic, 1 for shigella; 4 patients receiving iron sulphate showed positivity for E. coli enteropathogenic; 2 patients receiving micronized encapsulated iron and 2 with bisglycinated chelated iron showed positivity for E. coli enteropathogenic, 1 with Sucrosomial® iron showed positivity for yersinia enterocolica. Summary/Conclusion: Different type of iron supplements differently affect pathogen gut flora selection. Molecular complexes iron carriers probably influence differently pathogen selection. The most represented selected pathogen flora is E. coli entheropathogenic.