Open AccessPB1817 A STUDY OF SERUM ALBUMIN AND CALCIUM IN 93 PATIENTS WITH SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
Author(s) -
Gao X.,
Qiu H.,
Wang J.,
Duan L.,
Tian T.
Publication year - 2019
Publication title -
hemasphere
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.677
H-Index - 11
ISSN - 2572-9241
DOI - 10.1097/01.hs9.0000565772.46293.7c
Subject(s) - medicine , albumin , gastroenterology , calcium , serum albumin , hemophagocytic lymphohistiocytosis , endocrinology , immunology , disease
Background: Hemophagocytic lymphohistiocytosis is a fatal syndrome of overactive inflammation, which is caused by excessive cytokines released by abnormal cytotoxic T cells, NK cells and macrophages. According to the etiology, it can be divided into primary HLH and secondary HLH. Aims: To investigate the clinical significance of serum albumin levels and calcium concentrations in patients with secondary hemophagocytic lymphohistiocytosis. Methods: The clinical and laboratory data of 93 patients with newly diagnosed sHLH in 2013.4 to 2017.5, and 20 healthy controls were retrospectively analyzed. The patients were classified as the clinical remission group and the progression group according to the response criteria. To explore the changes of serum calcium concentrations and albumin levels in the patients, its correlations with other laboratory indexes and the impact on survival. Results: (1) The serum calcium concentrations and albumin levels in lymphoma‐related HLH group and non‐tumor HLH group were lower than control group (P < 0.001); The serum calcium concentrations and albumin levels in the clinical remission group after treatment was higher than that before treatment (P < 0.001), while in the progression group the serum calcium concentrations and albumin levels after treatment did not changed significantly (P > 0.05,P = 0.101). (2) The serum calcium concentrations in newly diagnosed sHLH patients was positively correlated with ANC, PLT, HGB (P < 0.05); The overall survival (OS) was significantly longer in patients with serum calcium concentration ≥1.88 mmol/L than that<1.88 mmol/L (P = 0.006). (3) The serum albumin levels in newly diagnosed sHLH patients was positively correlated with ANC, HGB (P < 0.05); The overall survival was longer in patients with serum albumin level ≥25.2 g/L than that<25.2 g/L (P = 0.005). Summary/Conclusion: The serum calcium concentrations and albumin levels have clinical significance for disease diagnosis, decision‐making therapy and treatment outcomes in the patients with sHLH.