PS1549 SELF‐REPORTED PHYSICAL ACTIVITY IS PREDICTIVE OF SURVIVAL IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (HCT)

Background: Increased physical activity is associated with improved survival in patients undergoing cancer treatment. However, the association of self‐reported physical activity and activity intensity with HCT outcomes is less clear. Aims: The goal of this study is to evaluate the relationship of self‐reported physical activity and HCT outcomes. Methods: Data was collected from the Moffitt Cancer Center Health Research Informatics and transplant databases. Between 01/01/2011 and 7/5/2018, 587 patients received an allogeneic HSCT and completed IPAQ short form. IPAQ scoring algorithm was used to ascertain metabolic equivalent of task‐minutes (MET‐minutes) per day. Based on MET‐minutes/day aggregate score, patients were subsequently divided into three activity categories: low (n = 337), moderate (n = 52), and vigorous (n = 198). Results: Median follow‐up was 41.7 months (range 11.4–267months). Patients with lower physical activity were older (Age = 59.67 [20.3–75.4] and had more comorbidities (HCT‐CI = 3 [0–9]), in comparison to patients with moderate and vigorous activity. Males reported vigorous activity more commonly (66.7%) in comparison to females (33.3%) whereas low activity level was similar for each gender (females 51.3%, males 48.7%). There was no significant difference in Karnofsky performance status (KPS), Armand disease risk, conditioning intensity, number of prior chemotherapy regimens, and cardiopulmonary function amongst the three categories (Table 1). Patients with vigorous physical activity had lower risk of NRM in comparison to low and moderate activity (Figure 1). In multivariate modeling, after accounting for KPS, graft‐versus host disease, and FEV1, physical activity level was an independent predictor of non‐relapse mortality with lower activity levels associated with increased risk of NRM (HR: low 1.7 (95% CI: 1.07–2.93); moderate 2.11 (95% CI: 1.03–4.31); overall P = 0.049). However, no association was seen between activity level and overall survival or relapse free survival (P = NS). Summary/Conclusion: Self‐reported vigorous activity prior to HCT is an independent predictor of NRM after HCT. This easy to employ tool can be of utility in the clinic to risk stratify HCT candidates. Further studies are warranted to evaluate impact of self‐reported physical activity on HCT outcomes.