Assessing Maternal Genetic Associations | Zendy

Jacqueline R. Starr | Zendy; Li Hsu | Zendy; Stephen M. Schwartz | Zendy

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Assessing Maternal Genetic Associations

Author(s) -

Jacqueline R. Starr,

Li Hsu,

Stephen M. Schwartz

Publication year - 2005

Publication title -

epidemiology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.901

H-Index - 173

eISSN - 1531-5487

pISSN - 1044-3983

DOI - 10.1097/01.ede.0000158223.98649.eb

Subject(s) - triad (sociology) , offspring , genotype , allele , in utero , case control study , logistic regression , biology , genetics , medicine , demography , pregnancy , psychology , fetus , sociology , gene , psychoanalysis

In utero exposures, including maternal phenotypes, are potential risk factors for both early-onset and adult-onset diseases. Two alternative study designs use maternal genotypes at polymorphic loci as biomarkers of an offspring's in utero exposure: (1) a traditional case-control study with logistic regression analysis, in which cases, controls, and mothers of both types of subjects are genotyped; and (2) a case-parent triad study with log-linear analysis, in which cases and both parents are genotyped.

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