Open AccessAssessing Maternal Genetic Associations
Author(s) -
Jacqueline R. Starr,
Li Hsu,
Stephen M. Schwartz
Publication year - 2005
Publication title -
epidemiology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.901
H-Index - 173
eISSN - 1531-5487
pISSN - 1044-3983
DOI - 10.1097/01.ede.0000158223.98649.eb
Subject(s) - triad (sociology) , offspring , genotype , allele , in utero , case control study , logistic regression , biology , genetics , medicine , demography , pregnancy , psychology , fetus , sociology , gene , psychoanalysis
In utero exposures, including maternal phenotypes, are potential risk factors for both early-onset and adult-onset diseases. Two alternative study designs use maternal genotypes at polymorphic loci as biomarkers of an offspring's in utero exposure: (1) a traditional case-control study with logistic regression analysis, in which cases, controls, and mothers of both types of subjects are genotyped; and (2) a case-parent triad study with log-linear analysis, in which cases and both parents are genotyped.