Open AccessThe Use of Allograft Skin for the Treatment of Darier Disease
Author(s) -
Carmine D’Acunto,
Catuscia Orlandi,
Valeria Purpura,
Davide Melandri
Publication year - 2020
Publication title -
advances in skin and wound care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 61
eISSN - 1538-8654
pISSN - 1527-7941
DOI - 10.1097/01.asw.0000694144.13825.59
Subject(s) - medicine , darier's disease , dermatology , disease , skin lesion , surgery , pathology
Darier disease is an autosomal dominant skin disorder characterized by keratotic papules. After their appearance, these lesions tend to grow over time, producing large and exudative plaques that compromise the general condition of the affected patient's skin. The authors report the clinical case of a patient affected by Darier disease with superinfected de-epithelialized areas over 30% of his body. In addition to antibiotic and antifungal therapy, providers used allograft skin to cover the injured areas and stimulate their progressive re-epithelialization with complete healing after 2 months. To the authors' knowledge, this is the first clinical case of treating Darier disease with allograft skin on an extensively damaged area. The effectiveness of this treatment may lead clinicians to consider allograft skin tissue a new, alternative dressing to treat Darier disease when this pathologic condition manifests with extensive eroded skin.