Open AccessEfficacy and Safety of Pirfenidone in Patients with Second-Degree Burns: A Proof-of-Concept Randomized Controlled Trial
Author(s) -
Gabriel A. Mecott,
Iván González-Cantú,
Edgar Gerardo Dorsey-Treviño,
Daniel Matta-Yee-Chig,
Odila SaucedoCárdenas,
Roberto Montes de OcaLuna,
Sergio Pérez-Porras,
Mauricio Manuel García-Pérez
Publication year - 2020
Publication title -
advances in skin and wound care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.426
H-Index - 61
eISSN - 1538-8654
pISSN - 1527-7941
DOI - 10.1097/01.asw.0000655484.95155.f7
Subject(s) - medicine , pirfenidone , randomized controlled trial , wound healing , confidence interval , burn wound , wound care , surgery , clinical trial , dermis , fibrosis , idiopathic pulmonary fibrosis , pathology , lung
Several studies suggest that pirfenidone may have a potential off-label use for wound healing. However, the effectiveness of this medication in patients with burns remains uncertain. Accordingly, investigators sought to assess wound re-epithelialization in patients with second-degree burns after adding pirfenidone to usual care.