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Clinical Significance of Soluble TNF Receptor in Japanese Patients with Non‐Alcoholic Steatohepatitis
Author(s) -
Tokushige Katsutoshi,
Hashimoto Etsuko,
Tsuchiya Noriko,
Kaneda Hiroyuki,
Taniai Makiko,
Shiratori Keiko
Publication year - 2005
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1097/01.alc.0000191810.46000.37
Subject(s) - steatohepatitis , fibrosis , medicine , gastroenterology , inflammation , tumor necrosis factor alpha , clinical significance , fatty liver , disease
A bstract : Background: Soluble tumor necrosis factor receptor (sTNFR) is reported to be a good indicator of TNF production and severity in inflammatory diseases. To investigate the clinical significance of sTNFR in non‐alcoholic steatohepatitis (NASH), we measured the serum levels of soluble TNF receptor‐1 and ‐2. Patients and Methods: We analyzed 82 NASH patients and 15 healthy subjects (control). The grades of fibrosis, inflammation and fatty deposit were evaluated on liver biopsy. The serum levels of sTNFR‐1 and ‐2 were measured by ELISA. Results: There was significant correlation between platelet count and sTNFRs. The titers of sTNFR‐2 in NASH patients with diabetes mellitus (DM) were higher than in those without DM. The serum levels of sTNFRs in NASH patients with advanced fibrosis were increased compared with those of control and NASH patients with low‐grade fibrosis. Soluble TNFRs in patients with moderate inflammation were increased compared to those of control and patients with mild inflammation. There was no significant association between fatty deposit grade and sTNFRs. Conclusion: Soluble TNFRs have a significant correlation with fibrosis in NASH.