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Is Ethanol a Pro‐Drug? Acetaldehyde Contribution to Brain Ethanol Effects
Author(s) -
Quertemont Etienne,
Eriksson C J. Peter,
Zimatkin Sergey M.,
Pronko Pavel S.,
Diana Marco,
Pisano Milena,
Rodd Zachary A.,
Bell Richard R.,
Ward Roberta J.
Publication year - 2005
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1097/01.alc.0000175015.51329.45
Subject(s) - acetaldehyde , ventral tegmental area , ethanol , dopaminergic , ethanol metabolism , alcohol , chemistry , psychology , neuroscience , pharmacology , dopamine , biochemistry , medicine
This article presents the proceedings of a symposium at the 2004 meeting of the International Society for Biomedical Research on Alcoholism, held in Mannheim, Germany. The symposium was organized by Etienne Quertemont and chaired by C. J. Peter Eriksson. The presentations were (1) Brain ethanol metabolism and its behavior consequences, by Sergey M. Zimatkin and P. S. Pronko; (2) Acetaldehyde increases dopaminergic neuronal activity: a possible mechanism for acetaldehyde reinforcing effects, by Marco Diana and Milena Pisano; (3) Contrasting the reinforcing actions of acetaldehyde and ethanol within the ventral tegmental area (VTA) of alcohol‐preferring (P) rats, by Zachary A. Rodd and Richard R. Bell; (4) Molecular and biochemical changes associated with acetaldehyde toxicity, by Roberta J. Ward; and (5) Role of acetaldehyde in human alcoholism and alcohol abuse, by C. J. Peter Eriksson.