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Neuroimaging of Rodent and Primate Models of Alcoholism: Initial Reports From the Integrative Neuroscience Initiative on Alcoholism
Author(s) -
Sullivan Edith V.,
Sable Helen J.K.,
Strother Wendy N.,
Friedman David P.,
Davenport April,
TillmanSmith Heather,
Kraft Robert A.,
Wyatt Christopher,
Szeliga Kendall T.,
Buchheimer Nancy C.,
Daunais James B.,
Adalsteinsson Elfar,
Pfefferbaum Adolf,
Grant Kathleen A.
Publication year - 2005
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1097/01.alc.0000153546.39946.ec
Subject(s) - neuroimaging , neuroscience , preclinical research , rodent model , psychology , alcohol dependence , magnetic resonance imaging , animal model , alcohol abuse , alcohol use disorder , functional magnetic resonance imaging , medicine , psychiatry , alcohol , biology , biochemistry , radiology
Neuroimaging of animal models of alcoholism offers a unique path for translational research to the human condition. Animal models permit manipulation of variables that are uncontrollable in clinical, human investigation. This symposium, which took place at the annual meeting of the Research Society on Alcoholism in Vancouver, British Columbia, Canada, on June 29th, 2004, presented initial findings based on neuroimaging studies from the two centers of the Integrative Neuroscience Initiative on Alcoholism funded by the National Institute on Alcohol Abuse and Alcoholism. Effects of alcohol exposure were assessed with in vitro glucose metabolic imaging of rat brain, in vitro receptor imaging of monkey brain, in vivo magnetic resonance imaging of monkey brain, and in vivo magnetic resonance spectroscopic quantification of alcohol metabolism kinetics in rat brain.