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CDT Values Are Not Influenced by Epithelial Cell Apoptosis in Chronic Alcoholic Patients—Preliminary Results
Author(s) -
Ramskogler Katrin,
Brunner Markus,
Hertling Ines,
Dvorak Alexander,
Kapusta Nestor,
Krenn Claus,
Moser Bernhard,
Roth Georg,
Lesch Otto Michael,
Ankersmit Hendrik Jan,
Walter Henriette
Publication year - 2004
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1097/01.alc.0000139818.68555.8a
Subject(s) - carbohydrate deficient transferrin , apoptosis , alcohol consumption , alcoholic liver disease , alanine aminotransferase , medicine , transferrin , gastroenterology , monoclonal antibody , antibody , endocrinology , immunology , alcohol , biology , biochemistry , cirrhosis
Carbohydrate‐deficient transferrin (CDT) has been well established as a marker for high alcohol consumption. As studies concerning the specificity of CDT in patients with liver disease have shown controversial outcomes, efforts to illuminate mechanisms leading to impaired CDT specificity in this patient group cannot yet be considered successful. Evidence of apoptosis as examined in 72 alcohol‐dependent patients using serum contents of caspase‐related M30 monoclonal antibody significantly correlated with aspartate aminotransferase, alanine aminotransferase, and γ‐glutamyl transpeptidase but did not influence CDT levels. These results suggest that impairment of CDT specificity is brought forth by derangement of hepatic metabolism rather than by acute hepatocellular damage.