Open AccessPrevalence of primary genotypic resistance in a UK centre: comparison of primary HIV-1 and newly diagnosed treatment-naive individuals
Author(s) -
Julie M. Fox,
Samantha V. Hill,
Steve Kaye,
Simon Dustan,
Myra O. McClure,
Sarah Fidler,
Nicola Mackie
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000247577.26375.ef
Subject(s) - human immunodeficiency virus (hiv) , genotype , medicine , drug resistance , lentivirus , antiretroviral drug , sida , hiv drug resistance , virology , antiretroviral treatment , immunology , antiretroviral therapy , viral load , pediatrics , viral disease , biology , genetics , gene
The worrying finding that up to 19% of newly diagnosed HIV-1 cases in the UK have genotypic evidence of transmitted drug-resistant HIV-1 (TrDR-HIV-1) does not concur with levels observed in one London centre. A study of the prevalence of resistance in primary HIV infection and newly diagnosed antiretroviral-naive individuals demonstrated significantly lower levels of TrDR-HIV-1 than previously reported. Variations in the prevalence of TrDR-HIV-1 may reflect the heterogeneity of methodologies and definitions used for resistance.