Open AccessTracing the origin of Brazilian HTLV-1 as determined by analysis of host and viral genes
Author(s) -
Luíz Carlos Júnior Alcântara,
Túlio de Oliveira,
Michelle Gordon,
Oliver G. Pybus,
Rita Elizabeth Moreira Mascarenhas,
Magda Oliveira Seixas,
Marilda de Souza Gonçalves,
Carol Hlela,
Sharon Cassol,
Bernardo Galvão–Castro
Publication year - 2006
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000216383.14808.13
Subject(s) - seroprevalence , virology , host (biology) , biology , haplotype , genetic diversity , virus , gene , transmission (telecommunications) , genetics , antibody , genotype , demography , population , serology , sociology , electrical engineering , engineering
We compared the genetic diversity of the Brazilian human T-cell lymphotropic virus type 1 isolates with those found in KwaZulu-Natal (KZN), South Africa, and with the genetic background of the hosts. The seroprevalence rate in KZN was 1.7%. All sequences belonged to the A subgroup. The presence of South African sequences in two different clusters from Brazil, and the finding of the beta-globin haplotype in infected hosts are consistent with the transmission of this virus from southern Africa to Brazil.