Open AccessLong-term statin use does not act on the temporal trend of CD4 cell count in patients on virologically effective HAART
Author(s) -
Roberto Manfredi,
Leonardo Calza,
Francesco Chiodo
Publication year - 2006
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000199822.49488.50
Subject(s) - medicine , statin , prospective cohort study , human immunodeficiency virus (hiv) , immunology , immune system
Pleiotropic features are attributed to statins and fibrates, and effects on laboratory markers of HIV disease progression have been claimed. To assess whether statins/fibrates have long-term effects on the immune recovery of patients on virologically effective HAART, a prospective, comparative study was conducted on 267 dyslipidemic patients treated with either statins, fibrates, or on a dietary exercise programme only. Quarterly assessment of CD4 cell counts showed no differences between groups, thus excluding in-vivo negative immunological effects during effective HAART.