Open AccessImmune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis
Author(s) -
G. Breton,
Homa AdleBiassette,
A. Therby,
J. Ramanoelina,
Laurence Choudat,
F. Bissuel,
Michel Huerre,
Françoise Dromer,
B. Dupont,
Olivier Lortholary
Publication year - 2006
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000199014.66139.39
Subject(s) - immune reconstitution inflammatory syndrome , histoplasmosis , medicine , immune system , immunology , immunopathology , histoplasma , aids related opportunistic infections , uveitis , human immunodeficiency virus (hiv) , pathology , sida , antiretroviral therapy , viral disease , viral load , histoplasma capsulatum
Four HIV-1-infected patients presented with unusual clinical manifestations in the course of disseminated histoplasmosis, including liver abscesses, compressive lymphadenitis, intestinal obstruction, uveitis and arthritis within a median of 45 days after initiation of highly active antiretroviral therapy (HAART). They had a median increase of 106 CD4 cells/mul and granulomas with caseation in three. Partial immune reconstitution induced by HAART during disseminated histoplasmosis either related to the variety capsulatum or duboisii may be associated with immune reconstitution inflammatory syndrome.