Open AccessHIV-infected progressors and long-term non-progressors differ in their capacity to respond to an A-class CpG oligodeoxynucleotide
Author(s) -
Raquel Sáez,
Pilar Echaniz,
Montse Juan,
José Antonio Iribarren,
Emilio Cuadrado
Publication year - 2005
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000191229.52385.5f
Subject(s) - immunology , cpg site , cpg oligodeoxynucleotide , innate immune system , immunity , human immunodeficiency virus (hiv) , virology , biology , immune system , gene , genetics , gene expression , dna methylation
We used an A-class CpG oligodeoxynucleotide to explore innate immunity in HIV infection and observed that natural killer cells from progressors showed a markedly lower IFN-gamma production in response to the oligonuclotide as compared with long-term non-progressing subjects and healthy HIV-negative individuals. This functional defect was found in patients who showed a long immunological reduction and in those who had had a recent reduction in their CD4 cell counts.