Open AccessPremature sister chromatid separation in HIV-1-infected peripheral blood lymphocytes
Author(s) -
Mari Shimura,
Kenzo Tokunaga,
Mitsuru Konishi,
Yukô Satô,
Chizuko Kobayashi,
Tetsutaro Sata,
Yukihito Ishizaka
Publication year - 2005
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000180788.92627.e7
Subject(s) - sister chromatids , aneuploidy , sister chromatid exchange , peripheral blood , genome instability , immunology , biology , incidence (geometry) , chromosome instability , chromatid , human immunodeficiency virus (hiv) , medicine , peripheral , virology , genetics , in vitro , chromosome , dna , dna damage , physics , optics , gene
To investigate the mechanism of aneuploidy that is frequently observed in AIDS, we examined premature sister chromatid separation (PCS), a sign of genomic instability, in peripheral blood cells of HIV-1-infected individuals. PCS was found in all six HIV-1 individuals at a high incidence. When peripheral blood cells from healthy volunteers were infected with HIV-1 in vitro, the incidence of PCS increased. This suggests that HIV-1 infection causes PCS and has the potential to induce aneuploidy.