Open AccessPersistence of primary drug resistance among recently HIV-1 infected adults
Author(s) -
Jason D. Barbour,
Frederick M. Hecht,
Terri Wrin,
Teri Liegler,
Clarissa A Ramstead,
Michael P. Busch,
Mark R. Segal,
Christos J. Petropoulos,
Robert M. Grant
Publication year - 2004
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/01.aids.0000131391.91468.ff
Subject(s) - drug resistance , virology , reverse transcriptase , viral replication , biology , viral load , virus , nucleoside reverse transcriptase inhibitor , reverse transcriptase inhibitor , hiv drug resistance , drug holiday , lentivirus , immunology , viral disease , human immunodeficiency virus (hiv) , antiretroviral therapy , gene , rna , genetics
Primary, or transmitted, drug resistance is common among treatment naive patients recently infected with HIV-1, and impairs response to anti-retroviral therapy. We previously observed that patients with secondary resistance (developed in response to anti-retroviral treatment) who chose to stop an anti-retroviral regimen experience rapid overgrowth of drug resistant viruses by wild-type virus of higher pol replication capacity. We sought to determine if primary drug resistance would be lost at a rapid rate, and viral pol replication capacity would increase, in the absence of treatment.