Open AccessRecruiting Volunteers for a Multisite Phase I/II HIV Preventive Vaccine Trial in Thailand
Author(s) -
Darawan Thapinta,
Richard A. Jenkins,
Patricia Morgan,
J. Kam Chiu,
Wantanee Boenim,
Valai Bussaratid,
Catherine Chaddic,
Supa Naksrisook,
Benjaluck Phonrat,
Nampueng Sirijongdee,
Pornchai Sornsathapornkul,
Auchara Sontirat,
Prasong Srisaengchai,
Chanmet Suwanarach,
Siriluck Wongkamhaeng,
Arthur E. Brown,
Chirasak Khamboonruang,
Sorachai Nitayaphan,
Punnee Pitisuttithum,
Prasert Thongchareon
Publication year - 2002
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/00126334-200208150-00006
Subject(s) - human immunodeficiency virus (hiv) , medicine , clinical trial , family medicine , psychology , demography , clinical psychology , sociology
Factors believed to be predictive of retention through the recruitment and screening processes for preventive HIV trials were investigated in a large multisite phase I/II HIV vaccine trial in Thailand. Retention through recruitment was equal to or greater than in previous smaller trials with similar populations. The data suggested that recruitment proceeded in a stepwise manner with different influences at each step. Demographic and motivational variables were most important in predicting retention in making and keeping screening appointments. Altruistic or mixed altruistic and nonaltruistic motives were associated with greater retention. Laboratory/medical variables appeared to be the main influence on retention during screening, although some volunteers withdrew for different reasons. The frequent presence of mixed (altruistic and nonaltruistic) motives at initial contact suggests that motivation for trials is more complex than has been previously acknowledged.